Importantly, Gerovital-H3® can help reduce cortisol levels. Cortisol is the hormone responsible for stress and a “rare” hormone in that it is one of the few that increases with age. It is believed that high-cortisol levels lead to accelerated aging because cortisol “attacks” the hypothalamus, (the area of the brain that “controls” the endocrine system). Ironically, cortisol may run out-of-control due to its ability to damage the hypothalamus that controls the adrenal glands that produce cortisol! Thus this vicious catch-22 situation leads to an impaired endocrine system and forms part of the Neuroendocrine Theory of Aging.
In a landmark 14 page paper with 62 references, Dr. Sapse made a that cortisol, the “state of siege” hormone secreted by the adrenal glands, could all by itself cause a host of the common mental and physical problems related to stress, aging and degenerative disease.
Over a lifetime cortisol damages the brain, muscle, bone, skin and the immune system. A key regulatory center of the brain, the hippocampus, may gradually lose 20% of its cells due to its unique sensitivity to cortisol damage. The hippocampus, a mid brain structure strategically seated above the hypothalamus/pituitary gland and below the cerebral cortex, plays a crucial role in cognition, attention, memory, emotional stability and sensory integration. It also plays a major role in regulating the hypothalamic – pituitary axis, which in turn regulates the entire endocrine (glandular) system of the human body.
Gerovital-H3® is also a reversible reducer the brain enzyme MAO, (a substance that breaks down neurotransmitters [and increases with age] having a detrimental effect on brain function), thus accounting for Gerovital-H3's anti-depressant affects.
Gerovital H3 has shown in several well designed studies as a treatment for depression. Significant improvements were reported in the mood and behavior of depressed patients taking GH3. In one study William W.K. Zung of Duke University in North Carolina concluded that Gerovital was more effective than imipramine in relieving depression.
In another study, S. Cohen and K.S. Ditman reported that most patients on GH3 “felt a greater sense of well-being and relaxation, slept better at night and many obtained some relief from depression and the discomforts of chronic inflammation or degenerative disease.
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